Research

The Medplant Network will be embarking on 15 new research projects facilitated by our partners around Europe. Please browse around our portfolio to find out more.

Project ESR1: Correlating evolutionary and chemical space using ChemGPS-NP.

Project ESR1: Correlating evolutionary and chemical space using ChemGPS-NP.

PhD-fellow: Astrid Henz Supervision: Prof. Anders Backlund Host Institution: Department of Pharmacognosy, Uppsala University Co-supervisors: Thierry Kogej, AstraZeneca In this project in-house databases comprising taxonomically annotated chemical data will be expanded and used to test if there is a correlation between phylogenetic advancement of a taxon, and molecular and/or biosynthetic complexity and volume of the ChemGPS-NP…

Project ESR2: Phylogeny and phytochemistry of Icelandic club mosses and lichens

Project ESR2: Phylogeny and phytochemistry of Icelandic club mosses and lichens

PhD-Fellow: Maonian Xu Supervision: Dr. Sesselja Omarsdottir Host Institution: Faculty of Pharmaceutical Sciences, University of Iceland Co-supervisors: Elin Olafsdottir, University of Iceland (P4), Starri Heidmarsson, Icelandic Institute of Natural History (AC3); Margret Thorsteinsdottir, ArcticMass (AC6). Lower plants are largely unstudied for new leads although they harbor unique chemistry. This project will use phylogeny and chemical profiling…

Project ESR3: Domesticating deadly carrots. Predicting the biosynthetic pathway of Thapsigargins for the treatment of solid tumours

Project ESR3: Domesticating deadly carrots. Predicting the biosynthetic pathway of Thapsigargins for the treatment of solid tumours

PhD-fellow: Karen Martinez Supervision: Dr. Henrik Toft Simonsen Host Institution: Department of Plant and Environmental Sciences, University of Copenhagen. Co-supervisors: Dr. Nina Rønsted, Natural History Museum of Denmark, University of Copenhagen; Dorian Marban, ThapsIbiza (AC1); Gary Martin, Global Diversity Foundation (AC2). This project will use phylogeny and chemical profiles to revise the genus Thapsia and…

Project ER1: Correlating evolutionary and chemical space using ChemGPS-NP.

Project ER1: Correlating evolutionary and chemical space using ChemGPS-NP.

Post.doc: Rosa Buonfiglio Supervision: Dr. Thierry Kogej Host Institution: AstraZeneca Co-supervisor: Prof. Anders Backlund, Department of Pharmacognosy, Uppsala University. This project will use and develop the ChemGPS-NP chemical property space model for chemographic analysis, and test models for cytotoxity and blood-brain barrier passage of small organic molecules for in-silico drug discovery with emphasis on natural products….

Project ESR7: Ethnobotany with the Chimalapas Zoque (Oaxaca, Mexico). Reconstructing pre-Columbian Macro- Mayan medicine

Project ESR7: Ethnobotany with the Chimalapas Zoque (Oaxaca, Mexico). Reconstructing pre-Columbian Macro- Mayan medicine

PhD Fellow: Matthias S. Geck Supervision: Dr. Marco Leonti and Prof. Micaela Morelli Host Institution: University of Cagliari Co-supervisors: Dr. Laura Casu University of Cagliari; Dr. Alberto Reyes García, Herbario Nacional de México (AC11). This project will conduct a quantitative cultural biodiversity study with the Chimalapa Zoque focusing on medical ethnobotany and local healing concepts. Such data will…

Project ESR8: History of medicinal plant use in Europe: A phylogenetic and organoleptic approach

Project ESR8: History of medicinal plant use in Europe: A phylogenetic and organoleptic approach

PhD Fellow: Peter Staub Supervision: Dr. Marco Leonti and Prof. Micaela Morelli Host Institution: University of Cagliari Co-supervisors: Dr. Julie Hawkins, School of Biological Sciences, University of Reading; Dr. Laura Casu University of Cagliari. This project will combine the results of molecular systematics with the uses described in the classical herbal texts together with the corresponding organoleptic properties…

Project ESR10: Cultural consensus and bioprospecting for anti-Chagas medicinal plants in Bolivia

Project ESR10: Cultural consensus and bioprospecting for anti-Chagas medicinal plants in Bolivia

PhD Fellow: Andrea Salm Supervision: Prof. Jürg Gertsch Host Institution: Institute of Biochemistry and Molecular Medicine, University of Bern. Co-supervisors:  Prof. Alberto Giménez Turba and Prof. Giovanna Rocio Almanza Vega, Department of Pharmaceutical Chemistry, Universidad Mayor de San Andres, Bolivia This project will use quantitative ethnobotanical and cultural consensus analysis to direct screening for novel anti-Chagas and…

Project ER2: Predicting in vivo CNS activity. High content evaluation of physiological network-effects of complex plant extracts.

Project ER2: Predicting in vivo CNS activity. High content evaluation of physiological network-effects of complex plant extracts.

Post.doc: Sujay Guha Supervision: Prof. Jürg Gertsch Host Institution: Institute of Biochemistry and Molecular Medicine, University of Bern. Co-supervisor: Egon Koch, Dr. Willmar Schwabe. The main objective of this project is to develop an interdisciplinary approach that combines chemical screens, analytical chemistry, biochemistry and genetics to identify natural products that might have an effect on neural…

Project ESR12: EDGE-MED. Identification of evolutionarily distinct, globally endangered and potentially valuable medicinal plant species

Project ESR12: EDGE-MED. Identification of evolutionarily distinct, globally endangered and potentially valuable medicinal plant species

PhD  Fellow: Paul Wennekes Supervision: Dr. Julie Hawkins Host Institution: School of Biological Sciences, University of Reading Co-supervisors: Dr. Félix Forest, Kew Gardens (AC4). This project will reconstruct a mega-phylogeny of European plants using published and newly generated sequence data, and use it to identify Evolutionarily Distinct and Globally Endangered (EDGE) species. Duration: 3 years –…